p53: The Gene that Cracked the Cancer Code

Bloomsbury Sigma #ad - Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. Through the personal accounts of key researchers, the blind alleys, as well as the huge excitement of the chase for new cures – the hype, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, the enthusiasm, the lost opportunities, and the thrilling breakthroughs.

If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. All of us have lurking in our DNA a most remarkable gene, which has a crucial job – it protects us from cancer. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide.

Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous.

p53: The Gene that Cracked the Cancer Code #ad - And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge. This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives.


The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Life-Saving Treatment

The Experiment #ad - In 1990, the philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. The discovery of a cancer-causing genetic mutation leads to a lifesaving miracle drug in this “absorbing, complex medical detective story” Kirkus Reviews. Philadelphia, 1959.

A scientist scrutinizing a single human cell detects a missing piece of DNA. A chronicle of scientific rigor and determination, The Philadelphia Chromosome celebrates a rare triumph in the battle against cancer while offering a blueprint for future research. One of the wall street journal’s 10 Best Nonfiction Books of 2013.

The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Life-Saving Treatment #ad - That scientist, david hungerford, has just stumbled on the starting point of modern cancer research?the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. Cancer research would never be the same. With extensive research and numerous personal interviews, science journalist Jessica Wapner reconstructs the decades-long journey from Hungerford’s discovery to a breakthrough, lifesaving treatment.


Absolutely Small: How Quantum Theory Explains Our Everyday World

AMACOM #ad - Fayer, professor of chemistry at Stanford University, uses examples from the everyday world to help you understand quantum science like never before. Exploring a range of scientific concepts--from particles of light, to probability, to states of matter, he provides readers the answers to questions like: What makes blueberries blue and strawberries red? Does sound really travels in waves? and Why does light behave so differently from any other phenomenon in the universe? Challenging without being intimidating and accessible but not condescending, to what makes greenhouse gases bad--in considerable depth, Absolutely Small liberates physics from its mathematical underpinnings so anyone with curiosity and imagination can explore its beauty.

Absolutely small develops your intuition for the very nature of things at their most basic and intriguing levels by demystifying the world of quantum science. Physics is a complex and daunting topic, but it is also deeply satisfying--even thrilling. And it is absolutely one you can understand. Just as we can understand the concept of gravity without solving a single equation, author Michael D.


The Immunotherapy Revolution: The Best New Hope For Saving Cancer Patients' Lives

Williams Cancer Institute #ad - He has pioneered a brand new less invasive, less toxic solution to treating cancer. Committed to further advance research in intra-tumoral immunotherapy and help those who are struggling financially to cover medical costs, Dr. Williams is donating all proceeds from this book for this cause. Grab your copy now, and discover the promising solution to cancer!

Williams is a board-certified radiologist, image-guided oncologist, researcher, and professor. Williams shares his most groundbreaking, shocking conclusions from his decades of in-depth research on cancer. He provides life-changing advice in the most critical and overlooked areas in cancer treatment and recovery.

The Immunotherapy Revolution: The Best New Hope For Saving Cancer Patients' Lives #ad - He is the founder and director of Interventional Oncology for the Williams Cancer Institute and adjunct professor at Case Western Reserve University. Jason R. Most of the medical field refuses to acknowledge the major problems with the way they treat cancer. So is there really a better way to heal from cancer against all odds? YES!In this eye-opening book, Dr.

He has personally developed a revolutionary medical treatment that will change the way we treat cancer – forever. Dr. The future of treating Cancer Has Finally Arrived.


Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

Random House #ad - Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science. Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. Unlike chemotherapy or radiation, Herceptin has no disabling side effects.

Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, patient activism, corporate decisions, ego, money, politics, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside.

Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. Dennis slamon, who tapped into hollywood money and glamour to help fund slamon's research; and marti Nelson, wife of television executive Brandon Tartikoff, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug.

Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer #ad - Five years later she remains cancer-free. Her-2 is the biography of herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. It works by inactivating her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors.


The First Cell: And the Human Costs of Pursuing Cancer to the Last

Basic Books #ad - Like when breath becomes air, the first cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear. Most new drugs add mere months to one's life at agonizing physical and financial cost. In the first cell, azra raza offers a searing account of how both medicine and our society mistreats cancer, how we can do better, and why we must.

A lyrical journey from hope to despair and back again, scientific, cultural, The First Cell explores cancer from every angle: medical, and personal. We spend $150 billion each year treating it, yet -- a few innovations notwithstanding -- a patient with cancer is as likely to die of it as one was fifty years ago.

The First Cell: And the Human Costs of Pursuing Cancer to the Last #ad - Indeed, raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. With the fascinating scholarship of the emperor of all Maladies and the deeply personal experience of When Breath Becomes Air, a world-class oncologist examines the current state of cancer and its devastating impact on the individuals it affects -- including herself.

We have lost the war on cancer.


The Breakthrough: Immunotherapy and the Race to Cure Cancer

Twelve #ad - We are immersed in the stories of the brave, desperate patients who try emerging therapies. We can't fail to see ourselves, our friends and our families in these stories. The wall street journalnew york times bestselling author charles graeber details the astonishing scientific discovery of the code to unleashing the human immune system to fight -- and possibly even cure -- cancer, in this "captivating and heartbreaking" The Wall Street Journal book, featuring interviews with 2018 Nobel Prize in Medicine award-winners James P.

The result is what many are calling cancer's "penicillin moment, " a revolutionary discovery in our understanding of cancer and how to beat it. In the breakthrough, new york times bestselling author of the good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science.

The Breakthrough: Immunotherapy and the Race to Cure Cancer #ad - Engaging. In Mr. Graeber's hands, the evolution of immuno-oncology is both captivating and heartbreaking. Allison and Tasuku Honjo. For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold?As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses-tricks that scientists have only recently discovered and learned to defeat.


Borrowed Time: The Science of How and Why We Age Bloomsbury Sigma

Bloomsbury Sigma #ad - She focusses inward – on what is going on in our bodies at the most basic level of the cells and genes as the years pass – to look for answers to why and how our skin wrinkles with age, our wounds take much longer to heal than they did when we were kids, and why words escape us at crucial moments in conversation.

This book explores these questions and many others through interviews with key scientists in the field of gerontology and with people who have interesting and important stories to tell about their personal experiences of ageing. Sometime before 2020, be greater than the number of 0–4 year olds, the number of people over 65 worldwide will, for the first time, and it will keep on rising.

But why and how do we age? Scientists have been asking this question for centuries, yet there is still no agreement. In borrowed time, sue armstrong tells the story of science's quest to understand ageing and to prevent or delay the crippling conditions so often associated with old age. There are a myriad competing theories, like well-worn shoes or a rusting car, from the idea that our bodies simply wear out with the rough and tumble of living, to the belief that ageing and death are genetically programmed and controlled.

Borrowed Time: The Science of How and Why We Age Bloomsbury Sigma #ad - The strains this is causing on society are already evident as health and social services everywhere struggle to cope with the care needs of the elderly. As featured on bbc radio 4's start the week'a rich, timely study for the era of "global ageing"' NatureThe ageing of the world population is one of the most important issues facing humanity in the 21st century – up there with climate change in its potential global impact.


All that Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes

Arcade #ad - Cutting through hype, she recounts her first dissection; her own first acquaintance with a loved one’s death; the mortal remains in her lab and at burial sites as well as scenes of violence, accident, murder, romanticism, and cliché, and criminal dismemberment; and about investigating mass fatalities due to war, or natural disaster, such as the 2004 Indian Ocean tsunami.

. It is a treat for csi junkies, murder mystery and thriller readers, and anyone seeking a clear-eyed guide to a subject that touches us all. Acclaimed by bestselling crime writers and fellow scientists alike, All That Remains is neither sad nor macabre. Dame sue black is an internationally renowned forensic anthropologist and human anatomist.

She has lived her life eye to eye with the grim reaper, and she writes vividly about it in this book, which is part primer on the basics of identifying human remains, part frank memoir of a woman whose first paying job as a schoolgirl was to apprentice in a butcher shop, and part no-nonsense but deeply humane introduction to the reality of death in our lives.

All that Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes #ad - Book of the year, 2018 saltire literary awards a crimereads best True Crime Book of the Month For fans of Caitlin Doughty, and CSI shows, Mary Roach, a renowned forensic scientist on death and mortality. While professor black tells of tragedy, she also infuses her stories with a wicked sense of humor and much common sense.

She uses key cases to reveal how forensic science has developed and what her work has taught her about human nature.


Persuadable: How Great Leaders Change Their Minds to Change the World

Harper Business #ad - As a leader, changing your mind has always been perceived as a weakness. Not anymore. In a world that’s changing faster than ever, successful leaders realize that a genuine willingness to change their own minds is the ultimate competitive advantage. Drawing on evidence from social science, and more, politics, are increasingly becoming liabilities—while humility, inconsistency, business consultant Al Pittampalli reveals why confidence, and conviction, history, consistency, and radical open-mindedness are powerful leadership assets.

In persuadable, you’ll learn how Ray Dalio became the most successful hedge fund manager in the world by strategically curbing confidence. How one nobel prize-winning scientist discovered the cause of ulcers by bravely doubting his own entrenched beliefs. Rife with actionable advice, Persuadable is an invaluable guide for today’s data-driven, results-oriented leader.

Persuadable: How Great Leaders Change Their Minds to Change the World #ad - Distilling cutting edge research from cognitive and social psychology, he shows you precisely how. You’ll learn how billy graham’s change of heart helped propel the civil rights movement, and how a young NFL linebacker’s radical new position may prove to alter the world of professional football as we know it.

Pittampalli doesn’t just explain why you should be persuadable. How alan mullaly saved ford Motor Company, not by staying the course, but by continually changing course.


The Invention of Science: A New History of the Scientific Revolution

Harper #ad - Here are the brilliant iconoclasts—galileo, Copernicus, Brahe, Newton, and many more curious minds from across Europe—whose studies of the natural world challenged centuries of religious orthodoxy and ingrained superstition. From gunpowder technology, and the telescope to the practice of conducting experiments, the discovery of the new world, movable type printing, and the concept of the fact, perspective painting, the laws of nature, Wotton shows how these discoveries codified into a social construct and a system of knowledge.

Ultimately, he makes clear the link between scientific discovery and the rise of industrialization—and the birth of the modern world we know. In this fascinating history spanning continents and centuries, historian David Wootton offers a lively defense of science, revealing why the Scientific Revolution was truly the greatest event in our history.

The Invention of Science: A New History of the Scientific Revolution #ad - The invention of science goes back five hundred years in time to chronicle this crucial transformation, exploring the factors that led to its birth and the people who made it happen. A companion to such acclaimed works as the age of wonder, a clockwork Universe, and Darwin’s Ghosts—a groundbreaking examination of the greatest event in history, the Scientific Revolution, and how it came to change the way we understand ourselves and our world.

We live in a world transformed by scientific discovery. Yet today, science and its practitioners have come under political attack. Wootton argues that the scientific Revolution was actually five separate yet concurrent events that developed independently, but came to intersect and create a new worldview.